While Novelda's XeThru X4 ultra-wideband(UWB) pulse radar, being a monitor device of human signal, has been used in many industries, it is worth to test its safety and influence in human body. Unfortunately, there is not many research report on safety assessment of the device in radiation-sensitive reproductive systems. In this experiment, C57 mice were directly irradiated by XeThru X4, and the control group was placed in a normal environment for continuous observation for 90 days. It was found that the sex hormone levels of C57 mice changed under XeThru X4 radar radiation, especially testosterone (T) and sex hormone binding protein (SHBG), but there was no statistical difference during the 90-day observation period. At the same time, a special phenomenon was observed in the experiment. C57 female mice showed different degrees of hair loss on the back after 60 days, and increased with the XeThru X4 radar irradiation time. However, this phenomenon was not observed in male mice under the same radiation and in normal environments C57 mice, which may be related to sex hormone levels. Other aspects of the damage to mice remain to be investigated.