Multimodal PSSMA-Functionalized GdF3 : Eu3+ (Tb3+ ) Nanoparticles for Luminescence Imaging, MRI, and X-Ray Computed Tomography

Chempluschem. 2019 Aug;84(8):1135-1139. doi: 10.1002/cplu.201900352.

Abstract

Biocompatible poly(4-styrenesulfonic acid-co-maleic acid)-stabilized GdF3 : Eu3+ (Tb3+ ) nanoparticles were obtained by a one-step coprecipitation method in ethylene glycol or water. The particles are very small (3 nm), have a narrow size distribution, and were detectable by fluorescence, magnetic resonance, and X-ray contrast imaging. These properties allow multimodal imaging, which has prospective applications in the simultaneous and detailed detection of diseased tissues.

Keywords: biocompatible; gadolinium fluoride; luminescence; magnetic resonance imaging; x-ray computed tomography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Europium / chemistry*
  • Fluorides / chemistry*
  • Gadolinium / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Maleates / chemistry*
  • Nanoparticles / chemistry*
  • Optical Imaging / methods*
  • Polystyrenes / chemistry*
  • Terbium / chemistry*
  • Tomography, X-Ray Computed / methods*

Substances

  • Maleates
  • Polystyrenes
  • poly(4-styrenesulfonic acid-co-maleic acid)
  • Terbium
  • Europium
  • Gadolinium
  • Fluorides