The Effect of the Phospholipid Bilayer Environment on Cholesterol Crystal Polymorphism

Neta Varsano; Fabio Beghi; Tali Dadosh; Nadav Elad; Eva Pereiro; Gilad Haran; Leslie Leiserowitz; Lia Addadi

doi:10.1002/cplu.201900121

The Effect of the Phospholipid Bilayer Environment on Cholesterol Crystal Polymorphism

Chempluschem. 2019 Apr;84(4):317. doi: 10.1002/cplu.201900121. Epub 2019 Mar 20.

Authors

Neta Varsano¹, Fabio Beghi², Tali Dadosh³, Nadav Elad³, Eva Pereiro⁴, Gilad Haran⁵, Leslie Leiserowitz⁶, Lia Addadi¹

Affiliations

¹ Department of Structural Biology, Weizmann Institute of Science, 234 Herzl Street, Rehovot, 76100, Israel.
² Department of Chemistry, Università Degli Studi di Milano, 20122, Milano, Italy.
³ Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.
⁴ MISTRAL Beamline-Experiments Division, ALBA Synchrotron Light Source, Cerdanyola del Valles, 08290, Barcelona, Spain.
⁵ Department of Chemical & Biological Physics, Weizmann Institute of Science, Rehovot, 76100, Israel.
⁶ Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel.

PMID: 31939223
DOI: 10.1002/cplu.201900121

Abstract

Invited for this month's cover are the group of Prof. Lia Addadi at the Weizmann Institute of Science, Israel and collaborators at the Università Degli Studi di Milano, Italy, and the ALBA Synchrotron Light Source, Spain. The front cover shows how cholesterol crystals form in macrophage cells and in lipid bilayers of different compositions. Cholesterol monohydrate stable triclinic crystals form in vitro as rhomb-shaped plates, whereas the monoclinic crystals fold into tubular or helical shapes. Read the full text of the article at 10.1002/cplu.201800632.

Publication types

Portrait

MeSH terms

Cholesterol / chemistry*
Crystallization
Humans
Lipid Bilayers / chemistry*
Phospholipids / chemistry*

Substances

Lipid Bilayers
Phospholipids
Cholesterol