In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry

Nopphon Weeranoppanant; Andrea Adamo

doi:10.1021/acsmedchemlett.9b00491

In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry

ACS Med Chem Lett. 2019 Dec 12;11(1):9-15. doi: 10.1021/acsmedchemlett.9b00491. eCollection 2020 Jan 9.

Authors

Nopphon Weeranoppanant^{1

2}, Andrea Adamo³

Affiliations

¹ Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen Road, Muang, Chonburi 02131, Thailand.
² School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong 21210 Thailand.
³ Zaiput Flow Technologies, 300 Second Avenue, Waltham, Massachusetts 02451, United States.

Abstract

In-line purification is an important tool for flow chemistry. It enables effective handling of unstable intermediates and integration of multiple synthetic steps. The integrated flow synthesis is useful for drug synthesis and process development in medicinal chemistry. In this article, we overview current states of in-line purification methods. In particular, we focus on four common methods: scavenger column, distillation, nanofiltration, and extraction. Examples of their applications are provided.