PARP6 acts as an oncogene and positively regulates Survivin in gastric cancer

Xiying Sun; Yun Zhang; Mingliang Chu; Lixin Wang; Hede Shen; Zhuxue Zhang; Jianjun Hu; Wei Yi; Wenxiu Yang; Xiaobo Ma

PARP6 acts as an oncogene and positively regulates Survivin in gastric cancer

Int J Clin Exp Pathol. 2018 May 1;11(5):2364-2371. eCollection 2018.

Authors

Xiying Sun¹, Yun Zhang¹, Mingliang Chu^{1

2}, Lixin Wang¹, Hede Shen¹, Zhuxue Zhang¹, Jianjun Hu¹, Wei Yi¹, Wenxiu Yang³, Xiaobo Ma⁴

Affiliations

¹ Department of Pathology, The Affiliated People's Hospital of Guizhou Medical University Guiyang, China.
² Central Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang, China.
³ Department of Pathology, The Affiliated Hospital of Guizhou Medical University Guiyang, China.
⁴ Department of Medicine, George Washington University School of Medicine and Health Sciences Washington, DC, USA.

PMID: 31938348
PMCID: PMC6958236

Abstract

Poly (ADP-ribose) polymerases 6 (PARP6) is a novel member of the PARP family. Previous studies focused mostly on the role of PARP6 in colorectal cancer; however, the role of PARP6 in gastric cancer is currently unclear. In the present study, we found a high-level expression of PARP6 in gastric cancer cells and PARP6 promoted cell proliferation, migration and invasion. Moreover, we found a positive correlation exists between PARP6 and Survivin, which contributes to tumor ongoing survival. In sum, our data suggest that PARP6 may contribute to gastric cancer progression by activating the Survivin pathway.

Keywords: PARP6; Survivin; gastric cancer.