Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression

Kelu Li; Hongmei Ma; Xiuyan Zheng; Yali Hu; Yue Wang; Kunpeng Zhang; Jiahan Chen; Yan Qi; Jinfang Jiang; Lijuan Pang; Lin Tao; Wenyi Gu; Feng Li; Hong Zou

Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression

Int J Clin Exp Pathol. 2018 Mar 1;11(3):1707-1711. eCollection 2018.

Authors

Kelu Li^{1

2}, Hongmei Ma², Xiuyan Zheng², Yali Hu², Yue Wang², Kunpeng Zhang², Jiahan Chen³, Yan Qi^{1

2}, Jinfang Jiang^{1

2}, Lijuan Pang^{1

2}, Lin Tao^{1

2}, Wenyi Gu⁴, Feng Li⁵, Hong Zou^{1

2}

Affiliations

¹ Department of Pathology, First Affiliated Hospital, Shihezi University Shihezi, China.
² Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Pathology, School of Medicine, Shihezi University, Ministry of Education of China Shihezi, China.
³ School of Medicine, Shihezi University Shihezi, China.
⁴ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland Brisbane, Australia.
⁵ Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.

PMID: 31938273
PMCID: PMC6958127

Abstract

Polo-like kinase1 (PLK1) is a new therapeutic target for osteosarcoma with good application prospects. Whether PLK1 is highly expressed in chondrosarcoma and whether PLK1 can be a potential therapeutic target for chondrosarcoma are worth exploring. However, PLK1 expression in chondrosarcoma is scarcely investigated. Therefore, we collected 11 cases of chondrosarcoma and 26 cases of osteochondroma with complete clinical pathological data and used immunohistochemical staining to detect the expression of PLK1 in chondrosarcoma and osteochondroma and then studied its significance and relationship with clinical pathological parameters. Our results showed that the positive expression rate of PLK1 in chondrosarcoma tissue (90.91%, 10/11) was significantly higher than the rate of osteochondroma tissues (53.85%, 14/26) (P<0.05). The expression of PLK1 enhanced gradually with the increase in histological grade (P<0.05). PLK1 was highly expressed in chondrosarcoma, and the high expression of PLK1 might be involved in cartilage tumor malignant progression.

Keywords: PLK1; chondrosarcoma; immunohistochemistry; osteochondroma.