Purpose: The purpose of the study was to evaluate adherence to prescribed antiepileptic drugs (AEDs) and influencing factors in children with epilepsy from western China.
Methods: In this cross-sectional study, children with epilepsy were recruited from Western China Second Hospital. Questionnaires were used to collect baseline patient data and medication adherence, which was assessed using the Morisky scale. An ordinal logistic regression model was used to examine the factors affecting medication adherence.
Results: In total, 399 children were included. The age of participants ranged from 0.3 to 17.8 years, with a male-to-female ratio of 1.36:1. Overall, 57.1% (228/399) had generalized seizures. Further, 21.3% (85/399) patients showed good adherence, 51.4% (205/399) moderate adherence, and 27.3% (109/399) poor adherence. Ordered multiclassification logistic regression analysis showed that the age of patient, type of epilepsy, total household income, and source of drug information were associated with adherence.
Conclusions: Medication adherence is not high in children with epilepsy from western China. Medication adherence is affected by many factors, and we suggest that efforts are focused on tailored approaches to epilepsy education and behavioral interventions for better adherence.
Keywords: Children; Epilepsy; Medication adherence; Questionnaire.
Copyright © 2019. Published by Elsevier Inc.