Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

Can Cheng; Zhenzhen Li; Xu Zhao; Chaoliang Liao; Jing Quan; Ann M Bode; Ya Cao; Xiangjian Luo

doi:10.1016/j.ejphar.2020.172922

Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

Eur J Pharmacol. 2020 Mar 5:870:172922. doi: 10.1016/j.ejphar.2020.172922. Epub 2020 Jan 11.

Authors

Can Cheng¹, Zhenzhen Li¹, Xu Zhao¹, Chaoliang Liao¹, Jing Quan¹, Ann M Bode², Ya Cao¹, Xiangjian Luo³

Affiliations

¹ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China.
² The Hormel Institute, University of Minnesota, Austin, MN, 55912, USA.
³ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China. Electronic address: luocsu@csu.edu.cn.

PMID: 31935398
DOI: 10.1016/j.ejphar.2020.172922

Abstract

Once the balance between lipid anabolism and catabolism is broken, metabolic disorder will occur in the organism and finally lead to metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD), obesity and cancer. No established therapeutic regimens for treating NAFLD and obesity exist yet. Many natural compounds are extracted from botany, fungi and marine organisms. Importantly, natural compounds are major sources of innovative medicine. In this review, we first elucidate the important roles of lipid metabolism in NAFLD, obesity and cancer. Next, we summarize the action mechanisms of natural compounds including alkaloid, polyphenol targeting lipid metabolism. Therefore, manipulating lipid metabolism to reduce fatty acid availability may be the starting point for improving or even curing lipid metabolism-related diseases. Alkaloid and polyphenol are promising candidates for metabolic diseases to ameliorate lipid metabolism abnormalities.

Keywords: Cancer; Lipid metabolism; Natural compound; Nonalcoholic fatty liver disease; Obesity.

Publication types

Review

MeSH terms

Alkaloids / chemistry*
Alkaloids / pharmacology
Animals
Biological Products / chemistry*
Biological Products / pharmacology
Drug Discovery
Fatty Acids / metabolism
Humans
Lipid Metabolism / drug effects*
Liver / metabolism
Liver Neoplasms / complications
Liver Neoplasms / drug therapy
Metabolic Diseases / drug therapy*
Molecular Structure
Non-alcoholic Fatty Liver Disease / complications
Non-alcoholic Fatty Liver Disease / drug therapy
Obesity / complications
Obesity / drug therapy
Plant Extracts / chemistry
Plant Extracts / pharmacology
Polyphenols / chemistry*
Polyphenols / pharmacology

Substances

Alkaloids
Biological Products
Fatty Acids
Plant Extracts
Polyphenols