Liposarcoma is one of the most common mesenchymal tumors, although liposarcomas that occur in the mediastinum are uncommon. We recently encountered a case of mediastinal well-differentiated liposarcoma with secondary myxoid changes and smooth muscle differentiation in a 54-year-old man. The patient reported a 20-day history of chest pain, and thorax computed tomography revealed a large and multilobulated mass with heterogeneous density in the posterior and anterior mediastinum, which extended to the right hemithorax. Resection was performed and a pathological analysis subsequently confirmed a diagnosis of well-differentiated liposarcoma. The patient experienced recurrence at 15 months after the surgery and subsequently died of heart failure.
Keywords: Mediastinal; atypical lipomatous tumor; smooth muscle differentiation; well-differentiated liposarcoma.
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