Background: There is an emerging concept that long noncoding RNAs (lncRNAs) are involved in tumorigenesis and could be used as biomarkers. However, the clinical significance of human translational regulatory lncRNA (treRNA) in CRC is largely unknown. The purpose of the study was to examine the value of treRNA as a biomarker in colorectal cancer patients.
Methods: treRNA expression was studied in 78 tumors and adjacent tissues in colorectal cancer patients using quantitative real-time PCR.
Results: treRNA was found to be highly expressed in colorectal cancer tissue in contrast to adjacent tissue (P<0.05). Moreover, positive correlation was found between high treRNA expression and lymph node metastasis (P<0.05). Patients with high treRNA expression were found with compromised overall survival (OS) compared with the low treRNA expression group, according to Kaplan-Meier analysis. Moreover, Cox regression model analysis suggested high expression of treRNA as an independent poor prognostic factor for CRC patients.
Conclusions: Overexpression of treRNA could be associated with lymphatic metastasis and compromised survival of CRC. treRNA has potential to be used as a new biomarker for CRC lymphatic metastasis and survival.
Keywords: colorectal cancer; lncRNA; lymphatic metastasis; survival; treRNA.
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