Non-invasive and Time-dependent Blood-sugar Monitoring via Breath-derived CO2 Correlation Using Gas Chromatograph with a Milli-whistle Gas Analyzer

Cheng-Huang Lin; Luo-Xian Wu; Kuan-Hao Chen; Hsu-Feng Lo; King-Chuen Lin; Toshio Kasai; Chien-Chung Chen; Chung-Hung Shih; Maria Carla Manzano; Gil Nonato Santos; Enrique Manzano; Derrick Ethelbhert Yu

doi:10.2116/analsci.19P407

Non-invasive and Time-dependent Blood-sugar Monitoring via Breath-derived CO₂ Correlation Using Gas Chromatograph with a Milli-whistle Gas Analyzer

Anal Sci. 2020 Jun 10;36(6):739-743. doi: 10.2116/analsci.19P407. Epub 2020 Jan 10.

Authors

Cheng-Huang Lin¹, Luo-Xian Wu², Kuan-Hao Chen², Hsu-Feng Lo², King-Chuen Lin³, Toshio Kasai^{3

4}, Chien-Chung Chen⁵, Chung-Hung Shih^{6

7}, Maria Carla Manzano², Gil Nonato Santos⁸, Enrique Manzano^{8

9}, Derrick Ethelbhert Yu¹⁰

Affiliations

¹ Department of Chemistry, National Taiwan Normal University, Tingchow Rd., Taipei, 10617, Taiwan. chenglin@ntnu.edu.tw.
² Department of Chemistry, National Taiwan Normal University, Tingchow Rd., Taipei, 10617, Taiwan.
³ Department of Chemistry, National Taiwan University, Roosevelt Rd., Taipei 10617, Taiwan.
⁴ Institute of Scientific and industrial Research, Osaka University, Ibaraki, Osaka, 567-0047, Japan.
⁵ Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Wu-Hsing St., Taipei, 11031, Taiwan.
⁶ School of Respiratory Therapy, Taipei Medical University, Wu-Hsing St., Taipei, 11031, Taiwan.
⁷ Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan.
⁸ Physics Department, De La Salle University, 2401 Taft Ave., Manila, 0922, Philippines.
⁹ Electronics and Communications Engineering Department, De La Salle University, 2401 Taft Ave., Manila, 0922, Philippines.
¹⁰ Chemistry Department, De La Salle University, 2401 Taft Ave., Manila, 0922, Philippines.

PMID: 31932522
DOI: 10.2116/analsci.19P407

Abstract

A clear and positive correlation between the CO₂ concentration and the blood-sugar level has been observed via a non-invasive and time-dependent monitoring of CO₂ concentration from human breath, which is carried out by using a home-made gas chromatography (GC)/milli-whistle compact analyzer. The time-dependent sampling of the CO₂ concentration correlated between 5.0 to 5.6% (1% = 10⁴ ppm) in accordance with blood-sugar level variations of 80 to 110 mg/dL. The analytical method results in a rapid, continuous and non-invasive determination of blood-sugar level via measurement of the CO₂ concentration exhaled from the lungs.

Keywords: CO2; Gas chromatography/milli-whistle compact analyzer; RQ index; human breath monitoring; non-invasive blood-sugar level measurement; respiration.

MeSH terms

Breath Tests*
Carbon Dioxide / blood*
Chromatography, Gas / instrumentation
Humans
Sugars / blood*
Time Factors

Substances

Sugars
Carbon Dioxide