First Occurrence of the OXA-198 Carbapenemase in Enterobacterales

Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01471-19. doi: 10.1128/AAC.01471-19. Print 2020 Mar 24.

Abstract

A carbapenem-resistant Citrobacter sp. was recovered from routine screening of multidrug-resistant bacteria. This isolate coproduced OXA-48 and OXA-198. OXA-48 was carried by the prototypical IncL plasmid, whereas OXA-198 was carried by a peculiar IncHI-type plasmid. This carbapenemase gene was inserted within a class 1 integron located on a conjugative plasmid. This report describes the first occurrence of OXA-198 in Enterobacterales.

Keywords: Citrobacter; Citrobacter pasteurii; carbapenemase; integrons; plasmid; β-lactamases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Carbapenem-Resistant Enterobacteriaceae / drug effects
  • Carbapenem-Resistant Enterobacteriaceae / genetics*
  • Carbapenem-Resistant Enterobacteriaceae / isolation & purification
  • Carbapenems / pharmacology
  • Cephalosporins / pharmacology
  • Citrobacter / drug effects*
  • Citrobacter / genetics*
  • Citrobacter / isolation & purification
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Penicillins / pharmacology
  • Plasmids / genetics
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Cephalosporins
  • Penicillins
  • beta-Lactamases
  • carbapenemase

Supplementary concepts

  • Citrobacter pasteurii