Regulation of immune-driven pathogenesis in Parkinson's disease by gut microbiota

Wenxia Zheng; Rongni He; Zhenxing Yan; Yaowei Huang; Wei Huang; Zhuoyi Cai; Yuying Su; Siqin Liu; Yiting Deng; Qing Wang; Huifang Xie

doi:10.1016/j.bbi.2020.01.009

Regulation of immune-driven pathogenesis in Parkinson's disease by gut microbiota

Brain Behav Immun. 2020 Jul:87:890-897. doi: 10.1016/j.bbi.2020.01.009. Epub 2020 Jan 10.

Authors

Wenxia Zheng¹, Rongni He², Zhenxing Yan¹, Yaowei Huang³, Wei Huang⁴, Zhuoyi Cai¹, Yuying Su¹, Siqin Liu¹, Yiting Deng¹, Qing Wang⁵, Huifang Xie⁶

Affiliations

¹ Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Gongye Avenue Middle, Guangzhou, Guangzhou 510282, China.
² Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Gongye Avenue Middle, Guangzhou, Guangzhou 510282, China; Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
³ Department of Neurology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdon Province 510515, China.
⁴ Shunde Hospital, Southern Medical University, 1 Jiazi Road, Lunjiao Town, Shunde District, Foshan, Guangdon Province 528308, China.
⁵ Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Gongye Avenue Middle, Guangzhou, Guangzhou 510282, China. Electronic address: denniswq@yahoo.com.
⁶ Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Gongye Avenue Middle, Guangzhou, Guangzhou 510282, China. Electronic address: xhffhx@126.com.

PMID: 31931152
DOI: 10.1016/j.bbi.2020.01.009

Abstract

Parkinson's disease (PD) is one of the most significant medical and social burdens of our time. The prevalence of PD increases with age and the number of individuals diagnosed with PD is expected to double from 6.9 million in 2015 to 14.2 million in 2040. To date, no drugs can stop the ongoing neurodegeneration caused by PD due to its unclear and complex pathogenic mechanisms. It has been wildly recognized that both gut microbiota and neuro-immunity are involved in the pathology of PD. In this review, we intend to provide a comprehensive overview of current knowledge on how gut microbiota involved in immune-driven pathogenesis of PD, and its potential as a new target of dietary and/or therapeutic interventions for PD.

Keywords: Gut microbiota; Immunity; Parkinson’s disease; T cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gastrointestinal Microbiome*
Humans
Parkinson Disease*