A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Yusuke Ohba; Minami Yamada-Fujiwara; Tadanori Minagawa; Suguru Watanabe; Yoko Okitsu; Yoshihiko Izumi; Junichi Kameoka; Shinichiro Takahashi

doi:10.4103/JLP.JLP_61_19

A case of myelodysplastic syndrome with t(10;18)(q26;q21)

J Lab Physicians. 2019 Oct-Dec;11(4):382-384. doi: 10.4103/JLP.JLP_61_19.

Authors

Yusuke Ohba¹, Minami Yamada-Fujiwara^{2

3}, Tadanori Minagawa⁴, Suguru Watanabe⁴, Yoko Okitsu^{5

6}, Yoshihiko Izumi¹, Junichi Kameoka², Shinichiro Takahashi^{1

6}

Affiliations

¹ Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
² Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
³ Division of Blood Transfusion and Cell Therapy, Tohoku University Hospital, Sendai, Japan.
⁴ Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
⁵ Department of Blood Transfusion, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
⁶ Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Abstract

An 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/μL), and low levels of red blood cells (2.65 × 10⁶/μL), hemoglobin (10.4 g/dL), and platelets (118,000/μL) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS-U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.

Keywords: Chromosome banding; myelodysplastic syndromes; t(10;18)(q26;q21).

Publication types

Case Reports