Loss of Functional Dentition is Associated with Cognitive Impairment

J Alzheimers Dis. 2020;73(4):1313-1320. doi: 10.3233/JAD-190971.

Abstract

Background: Although tooth loss is known to increase the risk of cognitive impairment and dementia, few studies have investigated the association between functional teeth including rehabilitated lost teeth and cognitive functionObjective:We investigated the associations of the numbers of functional teeth and functional occlusal units with cognitive impairment and cognitive function in late life.

Methods: The current study was conducted as a part of the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), a community-based elderly cohort study. We analyzed 411 participants who have agreed with the additional dental exam. Geriatric psychiatrists and neuropsychologists administered the Consortium to Establish a Registry for Alzheimer's disease Assessment Packet Clinical and Neuropsychological Assessment Battery to all participants, and dentists examined their dental status.

Results: Higher number of functional teeth (OR = 0.955, 95% CI = 0.914-0.997, p = 0.037) and higher number of functional occlusal units (OR = 0.900, 95% CI = 0.813-0.996, p = 0.042) were associated with lower odds of cognitive impairment. When we analyzed these relationships separated by the location of teeth, only the numbers of functional teeth (OR = 0.566, 95% CI = 0.373-0.857, p = 0.007) and functional occlusal units (OR = 0.399, 95% CI = 0.213-0.748, p = 0.004) in the premolar area were associated with lower odds of cognitive impairment.

Conclusion: Loss of functional teeth and functional occlusal units (especially in the premolar region) were associated with increased cognitive impairment.

Keywords: Cognitive impairment; dental prosthesis; occlusal unit; tooth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / complications
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / psychology
  • Bicuspid
  • Cognitive Aging
  • Cognitive Dysfunction / complications*
  • Cognitive Dysfunction / epidemiology
  • Cognitive Dysfunction / psychology*
  • Cohort Studies
  • Dentition*
  • Female
  • Humans
  • Independent Living
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Republic of Korea / epidemiology
  • Socioeconomic Factors
  • Tooth Loss / complications*
  • Tooth Loss / epidemiology
  • Tooth Loss / psychology*