Risk factors predisposing for recurrent laryngeal nerve palsy following thyroid malignancy surgery: experience from a tertiary oncology centre

Eur Arch Otorhinolaryngol. 2020 Apr;277(4):1199-1204. doi: 10.1007/s00405-020-05788-0. Epub 2020 Jan 11.

Abstract

Background: Postoperative recurrent laryngeal nerve (RLN) palsy is one of the major morbidities encountered after thyroid surgery. The risk further increases when surgery is performed for thyroid malignancies.

Methodology: A retrospective study of patients who underwent hemi, total or completion thyroidectomy at our institute between June 2017 to May 2019 were analyzed. We assessed factors that predisposed to the development of RLN palsy.

Results: The study comprised of 228 patients. A total of 400 nerves were at risk. The RLN palsy rate was 6.8% (n = 27). On univariate and multivariate analysis, the risk of RLN palsy was seen most with pT4a tumor (OR = 8.5), gross extra-thyroidal extension (ETE) (OR = 3.5) and tracheo-esophageal groove (TEG) (OR = 2.8) involvement, followed by aggressive histopathology, and central compartment node positivity.

Conclusion: pT4a tumors, gross ETE, and TEG involvement were the leading causes predisposing for the development of RLN palsy in our series.

Keywords: Central compartment dissection; Extra thyroidal extension; Papillary thyroid carcinoma; Recurrent laryngeal nerve; Thyroidectomy; Tracheo-esophageal groove.

MeSH terms

  • Humans
  • Recurrent Laryngeal Nerve
  • Retrospective Studies
  • Risk Factors
  • Thyroid Neoplasms* / epidemiology
  • Thyroid Neoplasms* / surgery
  • Thyroidectomy / adverse effects
  • Vocal Cord Paralysis* / epidemiology
  • Vocal Cord Paralysis* / etiology
  • Vocal Cord Paralysis* / surgery