Quinoline-based hydrazone for colorimetric detection of Co2+ and fluorescence turn-on response of Zn2

Liang-Liang Gao; Su-Ping Li; Yuan Wang; Wei-Na Wu; Xiao-Lei Zhao; Hui-Jun Li; Zhi-Hong Xu

doi:10.1016/j.saa.2020.118025

Quinoline-based hydrazone for colorimetric detection of Co²⁺ and fluorescence turn-on response of Zn²

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5:230:118025. doi: 10.1016/j.saa.2020.118025. Epub 2020 Jan 2.

Authors

Liang-Liang Gao¹, Su-Ping Li², Yuan Wang³, Wei-Na Wu⁴, Xiao-Lei Zhao¹, Hui-Jun Li¹, Zhi-Hong Xu⁵

Affiliations

¹ College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, PR China.
² Department of clinical Laboratory, The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo 454000, PR China.
³ College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, PR China. Electronic address: wangyuan08@hpu.edu.cn.
⁴ College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, PR China. Electronic address: wuwn08@hpu.edu.cn.
⁵ Key Laboratory of Chemo/Biosensing and Detection, School of Chemistry and Chemical Engineering, Xuchang University, 461000, PR China; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, PR China. Electronic address: xuzhihong1980@xcu.edu.cn.

PMID: 31927511
DOI: 10.1016/j.saa.2020.118025

Abstract

A quinoline-based hydrazone, namely, bis((quinolin-8-yl)methylene)carbonohydrazide (1), has been designed and synthesized, which could be used as a dual probe for selective recognition of Co²⁺ and Zn²⁺ by monitoring changes in absorption and fluorescence spectral pattern, respectively. The detection limits of 1 for these two ions are 0.21 and 0.66 μM, respectively. The complex formation between 1 and Co²⁺/Zn²⁺ is responsible for the detection process, as confirmed through several spectral methods and DFT calculations. The application of the as-synthesized sensor is demonstrated in Zn²⁺ imaging in living cells.

Keywords: Co(2+); Colorimetric sensor; Fluorescent sensor; Hydrazone; Quinoline; Zn(2+).

MeSH terms

Cations, Divalent / analysis
Cobalt / analysis*
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Hydrazones / chemistry*
Microscopy, Fluorescence
Models, Molecular
Optical Imaging
Quinolines / chemistry*
Zinc / analysis*

Substances

Cations, Divalent
Fluorescent Dyes
Hydrazones
Quinolines
Cobalt
Zinc