Intravesical Hydrogels as Drug Reservoirs

Heping Qiu; Hui Guo; Di Li; Yuchuan Hou; Tairong Kuang; Jianxun Ding

doi:10.1016/j.tibtech.2019.12.012

Intravesical Hydrogels as Drug Reservoirs

Trends Biotechnol. 2020 Jun;38(6):579-583. doi: 10.1016/j.tibtech.2019.12.012. Epub 2020 Jan 8.

Authors

Heping Qiu¹, Hui Guo¹, Di Li², Yuchuan Hou³, Tairong Kuang⁴, Jianxun Ding⁵

Affiliations

¹ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Department of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, PR China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
³ Department of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, PR China.
⁴ College of Material Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address: kuangtr@zjut.edu.cn.
⁵ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: jxding@ciac.ac.cn.

PMID: 31926600
DOI: 10.1016/j.tibtech.2019.12.012

Abstract

The complex environment in the bladder weakens the efficacy of intravesical therapy. Hydrogel-based drug delivery systems are poised to revolutionize the delivery of therapeutic agents to bladder lesion sites. This forum article highlights the prospective applications of hydrogels as drug reservoirs in treating chronic bladder diseases.

Keywords: controlled drug delivery; floating platform; hydrogel; intravesical therapy; mucoadhesion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / chemistry
Drug Carriers / therapeutic use
Drug Delivery Systems / trends*
Humans
Hydrogels / chemistry
Hydrogels / therapeutic use*
Urinary Bladder / cytology
Urinary Bladder / metabolism*

Substances

Drug Carriers
Hydrogels