Longitudinal visual acuity development in ZIKV-exposed children

Diego da Silva Lima; Luiz Claudio Portnoi Baran; Russell David Hamer; Marcelo Fernandes da Costa; Kallene Summer Vidal; Francisco Max Damico; Mirella Telles Salgueiro Barboni; Valtenice de Cássia Rodrigues de Matos França; Cristiane Maria Gomes Martins; Heydi Segundo Tabares; Sarah Leonardo Dias; Leonardo Aparecido Silva; Diego Decleva; Mayana Zatz; Ana Paula Antunes Pascalicchio Bertozzi; Rosa Estela Gazeta; Saulo Duarte Passos; Dora Fix Ventura

doi:10.1016/j.jaapos.2019.11.005

Longitudinal visual acuity development in ZIKV-exposed children

J AAPOS. 2020 Feb;24(1):23.e1-23.e6. doi: 10.1016/j.jaapos.2019.11.005. Epub 2020 Jan 8.

Authors

Diego da Silva Lima¹, Luiz Claudio Portnoi Baran², Russell David Hamer³, Marcelo Fernandes da Costa², Kallene Summer Vidal², Francisco Max Damico⁴, Mirella Telles Salgueiro Barboni⁵, Valtenice de Cássia Rodrigues de Matos França², Cristiane Maria Gomes Martins², Heydi Segundo Tabares², Sarah Leonardo Dias², Leonardo Aparecido Silva², Diego Decleva², Mayana Zatz⁶, Ana Paula Antunes Pascalicchio Bertozzi⁷, Rosa Estela Gazeta⁷, Saulo Duarte Passos⁷, Dora Fix Ventura²

Affiliations

¹ Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil. Electronic address: limads@usp.br.
² Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil.
³ Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil; Department of Psychology, Florida Atlantic University, Boca Raton, Florida.
⁴ Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil; Department of Ophthalmology, São Paulo Medical School, University of São Paulo, São Paulo, Brazil.
⁵ Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil; Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
⁶ Stem Cell and Human Genome Research Center, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
⁷ Jundiaí Medical School, Jundiaí, Brazil.

PMID: 31926367
DOI: 10.1016/j.jaapos.2019.11.005

Abstract

Purpose: To follow the visual acuity development of children exposed to or infected with the Zika virus (ZIKV) during gestation and to relate potential visual acuity deficits to their clinical condition.

Methods: In this prospective study, visual acuity was measured via Teller Acuity Cards in three groups of children: (1) those with confirmed ZIKV exposure (ZE) through the mother only, (2) those with confirmed infection (ZI), and (3) unaffected controls. Visual acuity was measured 2-4 times in each child during the first 30 months of age.

Results: The study included 22 children in the ZE group, 11 in the ZI group, and 27 controls. Visual acuity developed normally in both patient groups, including infected patients (ZI) that did not manifest clinical symptoms. In a small subgroup of patients with characteristics consistent with congenital Zika syndrome (CZS), visual acuity was within normative values, with the exception of single child with chorioretinal atrophy.

Conclusions: In this southeastern Brazil study cohort, visual acuity development seemed to progress normally in infected children without CZS symptoms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
Eye Infections, Viral / physiopathology*
Eye Infections, Viral / virology
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Prospective Studies
Vision Tests
Visual Acuity / physiology*
Zika Virus Infection / physiopathology*
Zika Virus Infection / virology
Zika Virus*