NLRC5: new cancer buster?

Mol Biol Rep. 2020 Mar;47(3):2265-2277. doi: 10.1007/s11033-020-05253-5. Epub 2020 Jan 10.

Abstract

Recent decades, there is significant progress in understanding the mechanisms of tumor progression and immune evasion. The newly discovered protein NLRC5 is demonstrated to participate in regulating cancer immune escape through enhancing MHC class I genes expression in certain tumors. Nevertheless, increasing evidence has revealed that NLRC5 is up-regulated in some other tumors and promote tumor development and progression. The purpose of this review is to describe the role of NLRC5 in tumors and discuss whether NLRC5 can be a potential target in cancer treatment.

Keywords: Immunotherapy; NLRC5; Tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Disease Progression
  • Disease Susceptibility*
  • Gene Expression Regulation, Neoplastic
  • Genes, MHC Class I
  • Humans
  • Immunologic Surveillance / genetics
  • Intracellular Signaling Peptides and Proteins / chemistry
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Neoplasms / drug therapy
  • Neoplasms / etiology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Organ Specificity
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Biomarkers, Tumor
  • Intracellular Signaling Peptides and Proteins
  • NLRC5 protein, human