Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Growth Horm IGF Res. 2020 Apr:51:1-5. doi: 10.1016/j.ghir.2019.12.004. Epub 2019 Dec 24.

Abstract

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

Keywords: Adipose tissue; Bone; Brain; Growth hormone receptor; Heart; IGF-I; Intestine; Liver; Macrophages; Tissue-specific.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / metabolism
  • Adipocytes / pathology
  • Animals
  • Blood Glucose / metabolism*
  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Brain / metabolism
  • Brain / pathology
  • Gene Knockout Techniques
  • Growth Hormone / metabolism*
  • Heart
  • Insulin / metabolism*
  • Insulin Resistance
  • Insulin-Like Growth Factor I / metabolism*
  • Intestinal Mucosa / metabolism
  • Intestines / pathology
  • Liver / metabolism
  • Liver / pathology
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Myocardium / metabolism
  • Myocardium / pathology
  • Receptors, Somatotropin / genetics*

Substances

  • Blood Glucose
  • Insulin
  • Receptors, Somatotropin
  • Insulin-Like Growth Factor I
  • Growth Hormone