Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT).
Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether nocturia is a circadian disorder; (c) to discuss the role of melatonin in nocturia; (d) to consider ambulatory urodynamic monitoring in evaluating patients with nocturia; (e) to explore studies of water handling in human compartments utilizing heavy water; and (f) to explore whether basic science is the key to understanding the treatment options for diminished bladder capacity in patients with nocturia.
Methods: A compendium of discussions of the role of experimental science in understanding the pathophysiology of nocturia is described herein.
Results and conclusions: Translational science will play an increasing role in understanding the pathophysiology of nocturia, which may result in improved treatment strategies.
Keywords: circadian rhythm; nocturia; nocturnal polyuria (NP); urodynamics; water handling.
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