Neuroimaging data indicate divergent mesial temporal lobe profiles in amyotrophic lateral sclerosis, Alzheimer's disease and healthy aging

Foteini Christidi; Efstratios Karavasilis; Michail Rentzos; Georgios Velonakis; Vasiliki Zouvelou; Sofia Xirou; Georgios Argyropoulos; Ioannis Papatriantafyllou; Varvara Pantolewn; Panagiotis Ferentinos; Nikolaos Kelekis; Ioannis Seimenis; Ioannis Evdokimidis; Peter Bede

doi:10.1016/j.dib.2019.104991

Neuroimaging data indicate divergent mesial temporal lobe profiles in amyotrophic lateral sclerosis, Alzheimer's disease and healthy aging

Data Brief. 2019 Dec 19:28:104991. doi: 10.1016/j.dib.2019.104991. eCollection 2020 Feb.

Authors

Foteini Christidi¹, Efstratios Karavasilis², Michail Rentzos¹, Georgios Velonakis², Vasiliki Zouvelou¹, Sofia Xirou¹, Georgios Argyropoulos², Ioannis Papatriantafyllou³, Varvara Pantolewn², Panagiotis Ferentinos⁴, Nikolaos Kelekis², Ioannis Seimenis⁵, Ioannis Evdokimidis¹, Peter Bede^{6

7

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Affiliations

¹ First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece.
² Second Department of Radiology, General University Hospital "Attikon", National and Kapodistrian University of Athens, Greece.
³ 3rd Age Day Care Center IASIS, Glyfada, Greece.
⁴ Second Department of Psychiatry, General University Hospital "Attikon", National and Kapodistrian University of Athens, Greece.
⁵ Department of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
⁶ Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.
⁷ Biomedical Imaging Laboratory, Sorbonne University, INSERM, Paris, France.
⁸ Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

Abstract

A prospective, standardised neuroimaging protocol was implemented to characterise mesial temporal lobe pathology in amyotrophic lateral sclerosis, Alzheimer's disease and healthy controls focusing on the evaluation of interconnected white and grey matter structures. "Hippocampal pathology in Amyotrophic Lateral Sclerosis: selective vulnerability of subfields and their associated projections" [1]. High-resolution diffusion tensor and structural imaging data were acquired on a 3 T MRI platform using standardised sequence parameters. The integrity of the fornix and the perforant pathway was assessed by tractography, to provide fractional anisotropy, axial diffusivity and radial diffusivity measures. Quantitative structural imaging was used to estimate the total intracranial volume, total hippocampal volumes and hippocampal subfield volumes for each participant. Raw white- and grey-matter measures, demographic and clinical data are available online at 'Mendeley Data'. Amyotrophic lateral sclerosis and Alzheimer's disease exhibit divergent hippocampal profiles.

Keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Healthy aging; Hippocampus; MRI; Mesial temporal lobe; Neuroimaging; Tractography.