The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Shih-Han Ko; Li-Min Huang; Woan-Yuh Tarn

doi:10.3389/fmicb.2019.02885

The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Front Microbiol. 2019 Dec 11:10:2885. doi: 10.3389/fmicb.2019.02885. eCollection 2019.

Authors

Shih-Han Ko^{1

2}, Li-Min Huang^{1

2}, Woan-Yuh Tarn³

Affiliations

¹ Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
² Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
³ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Abstract

A variety of pathogens take advantage of cellular heat shock proteins (HSPs) to complete their life cycle and exert pathogenic effects. MRJ (DNAJB6), a member of the heat shock protein 40 family, acts as a molecular chaperone for a wide range of cellular processes. MRJ mutations are linked to human diseases, such as muscular dystrophy and neurodegenerative diseases. There are two MRJ isoforms generated by alternative use of terminal exons, which differ in their C-terminus. This mini-review summarizes how these two MRJ isoforms participate differentially in viral production and virulence, and the possibility for MRJ as a therapeutic target.

Keywords: Hsp40; MRJ; heat shock protein; morpholino oligonucleotide; virus.

Publication types

Review