Laser scanning microscopy for control of skin decontamination efficacy from airborne particulates using highly absorbent textile nanofiber material in combination with PEG-12 dimethicone

Skin Res Technol. 2020 Jul;26(4):558-563. doi: 10.1111/srt.12830. Epub 2020 Jan 10.

Abstract

Background: The decontamination of the skin is indispensable if airborne particulate contaminants deposit on the skin surface. Skin washing can have adverse effects as by skin rubbing the particles can be transferred deeply into the hair follicles, where they can be entrapped for a period of more than 10 days. Thus, alternative skin decontamination strategies are necessary.

Materials and methods: For imaging the contaminants in the skin, sodium fluorescein-labeled soot particles of submicron size (≈600 nm) were visualized using laser scanning microscopy.

Results: In the present ex vivo pilot study on porcine ear skin, it was shown that sodium fluorescein-labeled soot particles of submicron size (≈600 nm) could be efficiently removed from the skin with highly absorbent textile nanofiber material, whose efficacy could be further increased by spraying the contaminated skin area with the viscous fluid PEG-12 dimethicone before textile application.

Conclusion: In case of skin contamination with particulates, the contact washing should be avoided due to rubbing particles deeply into the hair follicles, where they can accumulate for a long time and induce negative consequences. Efficient skin decontamination could include pretreatment of skin surface with the viscous fluid PEG-12 dimethicone and subsequent application of highly absorbent textile nanofiber material.

Keywords: contamination; desquamation; fluorescence spectroscopy; hair follicles; pollutants; skin protection; washing.

MeSH terms

  • Animals
  • Decontamination*
  • Dimethylpolysiloxanes
  • Microscopy, Confocal
  • Nanofibers*
  • Particulate Matter* / analysis
  • Pilot Projects
  • Skin Care* / methods
  • Skin Physiological Phenomena / drug effects
  • Swine
  • Textiles*

Substances

  • Dimethylpolysiloxanes
  • Particulate Matter
  • dimethicone