The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

Maximilian G Christ; Albrecht M Clement; Christian Behl

doi:10.1016/j.tins.2019.12.002

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

Trends Neurosci. 2020 Feb;43(2):79-81. doi: 10.1016/j.tins.2019.12.002. Epub 2020 Jan 6.

Authors

Maximilian G Christ¹, Albrecht M Clement¹, Christian Behl²

Affiliations

¹ Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
² Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany. Electronic address: cbehl@uni-mainz.de.

PMID: 31918966
DOI: 10.1016/j.tins.2019.12.002

Abstract

Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.

Keywords: ALS; ER; autophagy; neurodegeneration; sigma-1 receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autophagy
Humans
Neurodegenerative Diseases* / genetics
Proteostasis
Receptors, sigma* / genetics
Receptors, sigma* / metabolism
Sigma-1 Receptor

Substances

Receptors, sigma