Abstract
Gallium(iii) complexes with polypridyl ligands are shown to kill bulk osteosarcoma cells and osteosarcoma stem cells (OSCs) with up to nanomolar potency. The most effective complex induces apoptosis in osteosarcoma cells by damaging genomic DNA. To the best of our knowledge this is the first investigation into metal-based anti-OSC agents.
MeSH terms
-
Cell Line, Tumor
-
Cell Nucleus / chemistry
-
Cell Nucleus / metabolism
-
Cell Proliferation / drug effects
-
Cell Survival / drug effects
-
Coordination Complexes / chemistry
-
Coordination Complexes / metabolism
-
Coordination Complexes / pharmacology*
-
Gallium / chemistry*
-
Humans
-
Neoplastic Stem Cells / cytology
-
Neoplastic Stem Cells / drug effects*
-
Neoplastic Stem Cells / metabolism
-
Osteosarcoma / metabolism
-
Osteosarcoma / pathology
Substances
-
Coordination Complexes
-
Gallium