Neuroprotective racemic germacranolides from the roots of Chloranthus henryi

Abstract

Three pairs of new germacranolides, (+)/(-)-chlogermacrones A-C, along with two known analogues were obtained from the roots of Chloranthus henryi. Spectroscopic techniques and single-crystal X-ray crystallographic analyses were used for the structure elucidation of the compounds. All of the isolated compounds were tested for their neuroprotective effects on H₂O₂ damaged PC12 cells, compounds 3 and 5 increased cell viability from 43.4 ± 1.3% to 99.6 ± 8.7 and 68.1 ± 4.8% at 10 μM, respectively.

Keywords: Chloranthus henryi; Enantiomers; Germacranolides; Neuroprotective activities.