The last 2 decades have seen tremendous growth in programs to address first-episode psychosis, which typically affects adolescents and young adults. Open Dialogue is a program that has shown promise in FEP treatment in Finland and is gaining popularity internationally. Implementation of this model in cultural and health care contexts that differ from Finland has not been studied. We conducted a qualitative study as part of the first pilot study of Open Dialogue in the United States to understand factors critical for implementation of the model. We interviewed 6 clients, 10 family members, and 9 clinicians. They identified several unique and beneficial features of the approach, focusing particularly on the value of family involvement, transparency, respectfulness, and the collaborative nature of Open Dialogue. Contextual factors, particularly regarding funding for this model in the current United States health care environment, are key determinants to address for future implementation of Open Dialogue in the United States. (PsycInfo Database Record (c) 2021 APA, all rights reserved).