The case is reported of a 39-year-old severely obese woman who developed acute metabolic disorders after the administration of a short course of intravenous amiodarone. The main biological features were hypertriglyceridemia, hypoglycaemia, hyperlactatemia and hyperammonemia; all were reversible after amiodarone discontinuation. There was an associated rise in liver enzymes. However, the influence of co-factors on these metabolic disorders, such as acquired carnitine deficiency, severe obesity, a long-term course of pancreatitis, and abdominal infections, could not be excluded.
Keywords: amiodarone; beta-oxidation; fatty acids; hyperammonemia.
© 2019 Maximilien Cappe, Philippe Hantson, Mina Komuta, Marie-Françoise Vincent, Pierre- François Laterre, Ismaïl Ould-Nana, published by Sciendo.