A clinical pilot study of jawbone mineral density measured by the newly developed dual-energy cone-beam computed tomography method compared to calibrated multislice computed tomography

Hyun Jeong Kim; Ji Eun Kim; Jiyeon Choo; Jeonghee Min; Sungho Chang; Sang Chul Lee; Woong Beom Pyun; Kwang-Suk Seo; Myong-Hwan Karm; Ki-Tae Koo; In-Chul Rhyu; Hoon Myoung; Min-Suk Heo

doi:10.5624/isd.2019.49.4.295

A clinical pilot study of jawbone mineral density measured by the newly developed dual-energy cone-beam computed tomography method compared to calibrated multislice computed tomography

Imaging Sci Dent. 2019 Dec;49(4):295-299. doi: 10.5624/isd.2019.49.4.295. Epub 2019 Dec 24.

Authors

Hyun Jeong Kim¹, Ji Eun Kim², Jiyeon Choo², Jeonghee Min², Sungho Chang³, Sang Chul Lee³, Woong Beom Pyun⁴, Kwang-Suk Seo¹, Myong-Hwan Karm⁵, Ki-Tae Koo⁶, In-Chul Rhyu⁶, Hoon Myoung⁷, Min-Suk Heo⁸

Affiliations

¹ Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
² SMDsolution Co., Ltd., Seoul, Korea.
³ Ray Co., Ltd., Seongnam, Korea.
⁴ Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
⁵ Department of Dental Anesthesiology, Seoul National University Dental Hospital, Seoul, Korea.
⁶ Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
⁷ Department of Oral and Maxillofacial Surgery and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
⁸ Department of Oral and Maxillofacial Radiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Abstract

Purpose: This clinical pilot study was performed to determine the effectiveness of dual-energy cone-beam computed tomography (DE-CBCT) in measuring bone mineral density (BMD).

Materials and methods: The BMD values obtained using DE-CBCT were compared to those obtained using calibrated multislice computed tomography (MSCT). After BMD calibration with specially designed phantoms, both DE-CBCT and MSCT scanning were performed in 15 adult dental patients. Three-dimensional (3D) Digital Imaging and Communications in Medicine data were imported into a dental software program, and the defined regions of interest (ROIs) on the 3-dimensional surface-rendered images were identified. The automatically-measured BMD values of the ROIs (g/cm³), the differences in the measured BMD values of the matched ROIs obtained by DE-CBCT and MSCT 3D images, and the correlation between the BMD values obtained by the 2 devices were statistically analyzed.

Results: The mean BMD values of the ROIs for the 15 patients as assessed using DE-CBCT and MSCT were 1.09±0.07 g/cm³ and 1.13±0.08 g/cm³, respectively. The mean of the differences between the BMD values of the matched ROIs as assessed using DE-CBCT and calibrated MSCT images was 0.04±0.02 g/cm³. The Pearson correlation coefficient between the BMD values of DE-CBCT and MSCT images was 0.982 (r=0.982, P<0.001).

Conclusion: The newly developed DE-CBCT technique could be used to measure jaw BMD in dentistry and may soon replace MSCT, which is expensive and requires special facilities.

Keywords: Bone Mineral Density; Cone-Beam Computed Tomography; Dual Energy; Phantoms.