Primary Gastric Synovial Sarcoma in a Child: A Case Report and Review of the Literature

J Pediatr Hematol Oncol. 2021 Jan;43(1):e119-e122. doi: 10.1097/MPH.0000000000001688.

Abstract

Synovial sarcoma is a mesenchymal neoplasm that shows a specific t(X;18) translocation that leads to the formation of SS18-SSX gene fusions and is most commonly seen in soft tissues of the extremity. The gastrointestinal tract is a very rare site of involvement. We report a case of primary gastric synovial sarcoma in a 13-year-old male child. Synovial sarcoma should be included in the differential diagnosis when spindle cell neoplasms are encountered in the stomach. A high degree of suspicion, followed by the necessary immunohistochemistry and molecular studies, is required to make an accurate diagnosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Humans
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Prognosis
  • Sarcoma, Synovial / diagnosis*
  • Sarcoma, Synovial / genetics
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / genetics
  • Translocation, Genetic*

Substances

  • Oncogene Proteins, Fusion
  • SS18-SSX1 fusion protein