Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts

Nat Commun. 2020 Jan 8;11(1):104. doi: 10.1038/s41467-019-13683-4.

Abstract

The fidelity of group II intron self-splicing and retrohoming relies on long-range tertiary interactions between the intron and its flanking exons. By single-molecule FRET, we explore the binding kinetics of the most important, structurally conserved contact, the exon and intron binding site 1 (EBS1/IBS1). A comparison of RNA-RNA and RNA-DNA hybrid contacts identifies transient metal ion binding as a major source of kinetic heterogeneity which typically appears in the form of degenerate FRET states. Molecular dynamics simulations suggest a structural link between heterogeneity and the sugar conformation at the exon-intron binding interface. While Mg2+ ions lock the exon in place and give rise to long dwell times in the exon bound FRET state, sugar puckering alleviates this structural rigidity and likely promotes exon release. The interplay of sugar puckering and metal ion coordination may be an important mechanism to balance binding affinities of RNA and DNA interactions in general.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA / genetics
  • Exons
  • Fluorescence Resonance Energy Transfer
  • Introns
  • Ions / chemistry
  • Kinetics
  • Magnesium / chemistry*
  • Nucleic Acid Conformation
  • RNA / chemistry*
  • RNA / genetics
  • Single Molecule Imaging
  • Sugars / chemistry*

Substances

  • Ions
  • Sugars
  • RNA
  • DNA
  • Magnesium