Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

Acta Neuropathol. 2020 Mar;139(3):597-600. doi: 10.1007/s00401-019-02123-8. Epub 2020 Jan 7.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / genetics
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / genetics
  • Chromosomes, Human, Pair 1 / genetics
  • Chromosomes, Human, Pair 19 / genetics
  • DNA Methylation
  • Female
  • Histones / analysis*
  • Histones / genetics*
  • Humans
  • Immunohistochemistry
  • Isocitrate Dehydrogenase / genetics
  • Male
  • Oligodendroglioma / diagnosis*
  • Oligodendroglioma / genetics
  • Sensitivity and Specificity

Substances

  • Biomarkers, Tumor
  • Histones
  • Isocitrate Dehydrogenase
  • IDH1 protein, human