Achievement of long-term remission of disseminated histoplasmosis in an AIDS patient

Akihide Nakamura; Isao Tawara; Kazuko Ino; Takeshi Matsumoto; Akinobu Hayashi; Hiroshi Imai; Yasunori Muraosa; Katsuhiko Kamei; Naoyuki Katayama

doi:10.1016/j.mmcr.2019.12.012

Achievement of long-term remission of disseminated histoplasmosis in an AIDS patient

Med Mycol Case Rep. 2019 Dec 19:27:25-28. doi: 10.1016/j.mmcr.2019.12.012. eCollection 2020 Mar.

Authors

Akihide Nakamura^{1

2}, Isao Tawara², Kazuko Ino², Takeshi Matsumoto³, Akinobu Hayashi⁴, Hiroshi Imai⁴, Yasunori Muraosa⁵, Katsuhiko Kamei⁵, Naoyuki Katayama²

Affiliations

¹ Department of Hematology and Oncology, Suzuka General Hospital, 1275-53 Yasuzukacho-yamanohana, Suzuka, Mie, 513-8630, Japan.
² Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan.
³ Department of Transfusion Medicine and Cell Therapy, Mie University Hospital, Tsu, Mie, 514-8507, Japan.
⁴ Pathology Division, Mie University Hospital, Tsu, Mie, 514-8507, Japan.
⁵ Medical Mycology Research Center, Chiba University, Chiba, Chiba, 260-8673, Japan.

Abstract

Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is poor prognosis once it disseminated, especially in immunocompromised patients. A 50-year-old Japanese-Brazilian male with multiple cervical lymphadenopathies was diagnosed as disseminated histoplasmosis and acquired immunodeficiency syndrome (AIDS). Anti-fungal therapy was initiated followed by anti-retroviral therapy (ART). He achieved long-term remission by treatment with voriconazole. Here we report a case of an AIDS patient with disseminated histoplasmosis who achieved long-term survival in non-endemic area.

Keywords: Disseminated histoplasmosis; HIV/AIDS; Histoplasma capsulatum.

Publication types

Case Reports