Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis

Cells. 2020 Jan 1;9(1):107. doi: 10.3390/cells9010107.

Abstract

Bone marrow contains endothelial progenitor cells (EPCs) that, upon pro-angiogenic stimuli, migrate and differentiate into endothelial cells (ECs) and contribute to re-endothelialization and neo-vascularization. There are currently no reliable markers to characterize EPCs, leading to their inaccurate identification. In the past, we showed that, in a panel of tumors, some cells on the vessel wall co-expressed CD14 (monocytic marker) and CD31 (EC marker), indicating a putative differentiation route of monocytes into ECs. Herein, we disclosed monocytes as potential EPCs, using in vitro and in vivo models, and also addressed the cancer context. Monocytes acquired the capacity to express ECs markers and were able to be incorporated into blood vessels, contributing to cancer progression, by being incorporated in tumor neo-vasculature. Reactive oxygen species (ROS) push monocytes to EC differentiation, and this phenotype is reverted by cysteine (a scavenger and precursor of glutathione), which indicates that angiogenesis is controlled by the interplay between the oxidative stress and the scavenging capacity of the tumor microenvironment.

Keywords: angiogenesis; cancer; endothelial cells (ECs); endothelial progenitor cells (EPCs); monocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / pathology
  • Cell Differentiation
  • Cell Line, Tumor
  • Endothelial Progenitor Cells / pathology*
  • Female
  • Human Umbilical Vein Endothelial Cells / metabolism
  • Humans
  • Mice, Inbred BALB C
  • Mice, SCID
  • Models, Biological
  • Monocytes / pathology*
  • Neoplasms / blood supply*
  • Neoplasms / pathology*
  • Neovascularization, Pathologic / pathology*
  • Reactive Oxygen Species / metabolism
  • Tumor Burden
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Reactive Oxygen Species
  • Vascular Endothelial Growth Factor A