Organophosphate insecticide exposure and telomere length in U.S. adults

Abstract

Background: Organophosphate insecticides have been widely used for >30 years, and are reported to be associated with various age-related chronic diseases. While shortening of telomere length has been considered as a marker of cellular aging, only a few small studies have been conducted to examine any difference of telomere length in workers exposed to organophosphates versus controls. Epidemiologic studies of the dose-response associations between environmental organophosphate exposure and telomere length in the general population are few.

Objective: This study aimed to evaluate the association between levels of organophosphate insecticide exposure and telomere length in the general population.

Methods: We analyzed data for 1724 participants aged 20 years or more from the National Health and Nutrition Examination Survey 1999-2002. Organophosphate insecticide exposure was estimated using measures of urinary concentrations for 3,5,6-trichloro-2-pyridinol (TCPY) and six non-specific dialkyl phosphate metabolites, e.g., diethyl thiophosphate (DETP). Multiple linear regression was conducted to assess the association between organophosphate exposure and telomere length.

Results: After controlling for sociodemographic and physical factors and urinary creatinine, participants in the second quartile for urinary TCPY had 0.06 (95% CI: 0.02-0.10) T/S ratio shorter telomere length than those in the lowest quartile. By contrast, participants in the second and third tertiles of urinary DETP had 0.08 (95% CI: 0.02-0.14) and 0.06 (95% CI, 0.01-0.11) T/S ratio longer telomere length than those in the lowest tertile. For other five metabolites, there was no association with telomere length.

Conclusions: Levels of environmental exposures to certain organophosphate insecticides may be linked to altered telomere length in adults in the general population. Although our findings may need to be replicated, we provide the first evidence that environmental exposure to organophosphates may contribute to the alteration of telomere length, which is potentially related to biological aging and to the development of various chronic diseases.

Keywords: Aging; Epidemiology; NHANES; Organophosphate insecticide; Telomere length.