Circular RNAs and their emerging roles as diagnostic and prognostic biomarkers in ovarian cancer

Rong Sheng; Xiaoduan Li; Ziliang Wang; Xipeng Wang

doi:10.1016/j.canlet.2019.12.043

Circular RNAs and their emerging roles as diagnostic and prognostic biomarkers in ovarian cancer

Cancer Lett. 2020 Mar 31:473:139-147. doi: 10.1016/j.canlet.2019.12.043. Epub 2020 Jan 2.

Authors

Rong Sheng¹, Xiaoduan Li², Ziliang Wang¹, Xipeng Wang³

Affiliations

¹ Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
² Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
³ Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Electronic address: wangxipeng@xinhuamed.com.cn.

PMID: 31904484
DOI: 10.1016/j.canlet.2019.12.043

Abstract

Ovarian cancer (OC), one of the gynecologic malignancies with high invasive and metastatic potential, has a low survival rate in females. Although cytoreductive surgery combined with chemotherapy is the principal treatment for OC, the prognosis remains poor, and the recurrence rate of OC remains high. It is urgent to explore novel biomarkers for the diagnosis and prognosis of OC, as well as therapeutic targets. Circular RNAs (circRNAs) are a class of highly conserved, stable and abundant noncoding RNAs (ncRNAs). Recent studies have shown that circRNAs participate in OC progression by regulating various processes, including cell proliferation, migration, invasion and apoptosis. In addition, circRNAs are potential biomarkers for OC diagnosis and prognosis. This review provides an overview of recent findings on circRNAs in OC, including their functions and molecular mechanisms, and discusses their potential roles as diagnostic and prognostic biomarkers, as well as therapeutic targets for OC.

Keywords: EMT; Exosome; Heterogeneity; MicroRNA sponge; Therapeutic target.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Apoptosis / genetics
Biomarkers, Tumor / antagonists & inhibitors
Biomarkers, Tumor / isolation & purification*
Biomarkers, Tumor / metabolism
Carcinogenesis / drug effects
Carcinogenesis / genetics
Cell Movement / genetics
Cell Proliferation / genetics
Chemotherapy, Adjuvant
Cytoreduction Surgical Procedures
Disease Progression
Disease-Free Survival
Drug Resistance, Neoplasm / drug effects
Drug Resistance, Neoplasm / genetics
Female
Gene Expression Regulation, Neoplastic / drug effects
Humans
MicroRNAs / metabolism
Neoplasm Invasiveness / genetics
Neoplasm Recurrence, Local / diagnosis*
Neoplasm Recurrence, Local / epidemiology
Neoplasm Recurrence, Local / genetics
Neoplasm Recurrence, Local / pathology
Ovarian Neoplasms / diagnosis*
Ovarian Neoplasms / genetics
Ovarian Neoplasms / mortality
Ovarian Neoplasms / therapy
Ovary / pathology*
Ovary / surgery
Prognosis
RNA, Circular / analysis*
RNA, Circular / antagonists & inhibitors
RNA, Circular / metabolism

Substances

Antineoplastic Agents
Biomarkers, Tumor
MicroRNAs
RNA, Circular