Sialic acids rather than glycosaminoglycans affect normal and sickle red blood cell rheology by binding to four major sites on fibrinogen

Frank Gondelaud; Philippe Connes; Elie Nader; Céline Renoux; Romain Fort; Alexandra Gauthier; Philippe Joly; Sylvie Ricard-Blum

doi:10.1002/ajh.25718

Sialic acids rather than glycosaminoglycans affect normal and sickle red blood cell rheology by binding to four major sites on fibrinogen

Am J Hematol. 2020 Apr;95(4):E77-E80. doi: 10.1002/ajh.25718. Epub 2020 Jan 15.

Authors

Frank Gondelaud¹, Philippe Connes^{2

3}, Elie Nader^{2

3}, Céline Renoux^{2

3

4}, Romain Fort^{2

3

5}, Alexandra Gauthier^{2

3

6}, Philippe Joly^{2

3

4}, Sylvie Ricard-Blum¹

Affiliations

¹ Univ Lyon, University Claude Bernard Lyon 1, CNRS, INSA Lyon, CPE, Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), Villeurbanne, France.
² Univ Lyon, University Claude Bernard Lyon 1 EA 7424, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM), Equipe "Biologie Vasculaire et du Globule Rouge", Villeurbanne, France.
³ Laboratoire d'Excellence GR-Ex, Paris, France.
⁴ Laboratoire de Biochimie et de Biologie Moléculaire, UF de biochimie des pathologies érythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, France.
⁵ Département de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
⁶ Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.

PMID: 31903639
DOI: 10.1002/ajh.25718

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell / blood*
Binding Sites
Chondroitin ABC Lyase / pharmacology
Erythrocyte Aggregation / drug effects*
Erythrocyte Deformability / drug effects*
Erythrocyte Membrane / chemistry
Erythrocyte Membrane / metabolism*
Fibrinogen / chemistry
Fibrinogen / metabolism*
Glycocalyx / chemistry
Glycosaminoglycans / antagonists & inhibitors
Hemorheology
Humans
Hyaluronoglucosaminidase / pharmacology
Models, Molecular
Molecular Docking Simulation
Neuraminidase / pharmacology
Polysaccharide-Lyases / pharmacology
Protein Binding
Protein Conformation
Sialic Acids / antagonists & inhibitors
Sialic Acids / blood*

Substances

Glycosaminoglycans
Sialic Acids
Fibrinogen
Neuraminidase
Hyaluronoglucosaminidase
Polysaccharide-Lyases
Chondroitin ABC Lyase
heparitinsulfate lyase