The changing face of paediatric diabetes

Diabetologia. 2020 Apr;63(4):683-691. doi: 10.1007/s00125-019-05075-6. Epub 2020 Jan 2.

Abstract

The purpose of this review is to provide an update on the changing face of paediatric type 1 diabetes and type 2 diabetes. Paediatric diabetes is on the rise, with extensive research dedicated to understanding its pathophysiology, comorbidities and complications. As obesity continues to increase among all youth, differentiating between type 1 diabetes and type 2 diabetes has become increasingly difficult but remains important for optimising treatment, anticipating complications and predicting disease risk. Novel treatments are emerging, with the ultimate goal being to achieve glycaemic control, limit weight gain, improve quality of life and reduce comorbidities. In this review, we focus on updates regarding the epidemiology, clinical presentation, comorbidities and complications of paediatric type 1 diabetes and type 2 diabetes and conclude with current and emerging treatments.

Keywords: Complications; Diabetes; Insulin; Metformin; Paediatrics; Review; Type 1 diabetes; Type 2 diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Age of Onset
  • Child
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / therapy
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / etiology
  • Diabetes Mellitus, Type 1 / therapy
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / therapy
  • Endocrinology / methods
  • Endocrinology / trends*
  • Humans
  • Pediatric Obesity / complications
  • Pediatric Obesity / epidemiology
  • Pediatric Obesity / therapy
  • Pediatrics / methods
  • Pediatrics / trends*
  • Risk Factors