BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

J Mol Cell Biol. 2020 Jun 11;12(5):397-399. doi: 10.1093/jmcb/mjz114.
No abstract available

Keywords: CRISPR-Cas9; ERG; RUNX1; STAG2; chromatin; cohesin; enhancer; inducible; megakaryocyte.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azepines / pharmacology
  • Base Sequence
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Core Binding Factor Alpha 2 Subunit / genetics*
  • Core Binding Factor Alpha 2 Subunit / metabolism
  • Gene Expression Regulation, Leukemic*
  • Humans
  • K562 Cells
  • Leukemia / genetics*
  • Mutation / genetics*
  • Proteins / antagonists & inhibitors*
  • Proteins / metabolism
  • Transcription, Genetic*
  • Transcriptional Regulator ERG / genetics
  • Transcriptional Regulator ERG / metabolism
  • Triazoles / pharmacology

Substances

  • (+)-JQ1 compound
  • Azepines
  • Cell Cycle Proteins
  • Core Binding Factor Alpha 2 Subunit
  • ERG protein, human
  • Proteins
  • STAG2 protein, human
  • Transcriptional Regulator ERG
  • Triazoles
  • bromodomain and extra-terminal domain protein, human