Early progression of disease predicts shorter survival in MALT lymphoma patients receiving systemic treatment

Haematologica. 2020 Nov 1;105(11):2592-2597. doi: 10.3324/haematol.2019.237990.

Abstract

Early progression of disease (POD) within two years from diagnosis is linked with poor overall survival (OS) in follicular lymphoma but its prognostic role is less clear in extranodal marginal zone B-cell lymphoma (EMZL). We sought to identify prognostic factors associated with early POD and to determine whether is associated with inferior OS. We analyzed the impact of early POD in the IELSG19 clinical trial dataset (training set of 401 patients randomly assigned to chlorambucil or rituximab or chlorambucil plus rituximab). Reproducibility was examined in a validation set of 287 patients who received systemic treatment. In both sets, we excluded from the analysis the patients who, within 24 months from treatment start, died without progression or were lost to follow-up without prior progression. OS was calculated from progression in patients with early POD and from 24 months after start of treatment in those without (reference group). Early POD was observed in 69 of the 384 (18%) evaluable patients of the IELSG19 study. Patients with high-risk MALT-IPI were more likely to have early POD (p=0.006). The 10-year OS rate was 64% in the early POD group and 85% in the reference group (HR= 2.42, 95%CI, 1.35-4.34; log-rank P=0.002). This prognostic impact was confirmed in the validation set, in which early POD was observed in 64 out of 224 (29%) evaluable patients with 10-year OS rate of 48% in the early POD group and 71% in the reference group (HR= 2.15, 95%CI, 1.19-3.90; log-rank P=0.009). In patients with EMZL who received front-line systemic treatment, early POD is associated with poorer survival and may represent a useful endpoint in future prospective clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Disease-Free Survival
  • Humans
  • Lymphoma, B-Cell, Marginal Zone* / diagnosis
  • Lymphoma, B-Cell, Marginal Zone* / drug therapy
  • Lymphoma, Follicular* / drug therapy
  • Prognosis
  • Reproducibility of Results
  • Rituximab / therapeutic use

Substances

  • Rituximab

Grants and funding

Funding This work was partly supported by the International Extranodal Lymphoma Study Group; by a grant from Oncosuisse (ICP OCS-01356-03-2003); AIRC 5 x 1000 (n. 21198), AIRC, Milan, Italy; and the AGING Project, Department of Excellence (DIMET), Universita’ del Piemonte Orientale, Novara, Italy. The IELSG-19 clinical trial was supported in part by an unrestricted research grant from Roche International, Ltd. The funders had no role in study design, data collection, analysis, and interpretation, or writing of the report.