Well-Child Care Adherence After Intrauterine Opioid Exposure

Pediatrics. 2020 Feb;145(2):e20191275. doi: 10.1542/peds.2019-1275. Epub 2020 Jan 2.

Abstract

Background and objectives: For children with intrauterine opioid exposure (IOE), well-child care (WCC) provides an important opportunity to address medical, developmental, and psychosocial needs. We evaluated WCC adherence for this population.

Methods: In this retrospective cohort study, we used PEDSnet data from a pediatric primary care network spanning 3 states from 2011 to 2016. IOE was ascertained by using physician diagnosis codes. WCC adherence in the first year was defined as a postnatal or 1-month visit and completed 2-, 4-, 6-, 9-, and 12-month visits. WCC adherence in the second year was defined as completed 15- and 18-month visits. Gaps in WCC, defined as ≥2 missed consecutive WCC visits, were also evaluated. We used multivariable regression to test the independent effect of IOE status.

Results: Among 11 334 children, 236 (2.1%) had a diagnosis of IOE. Children with IOE had a median of 6 WCC visits (interquartile range 5-7), vs 8 (interquartile range 6-8) among children who were not exposed (P < .001). IOE was associated with decreased WCC adherence over the first and second years of life (adjusted relative risk 0.54 [P < .001] and 0.74 [P < .001]). WCC gaps were more likely in this population (adjusted relative risk 1.43; P < .001). There were no significant adjusted differences in nonroutine primary care visits, immunizations by age 2, or lead screening.

Conclusions: Children <2 years of age with IOE are less likely to adhere to recommended WCC, despite receiving on-time immunizations and lead screening. Further research should be focused on the role of WCC visits to support the complex needs of this population.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Appointments and Schedules
  • Child Health / statistics & numerical data*
  • Child Health Services / statistics & numerical data*
  • Databases, Factual / statistics & numerical data
  • Female
  • Humans
  • Infant
  • Opioid-Related Disorders*
  • Outcome Assessment, Health Care
  • Patient Compliance / ethnology
  • Patient Compliance / statistics & numerical data*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Regression Analysis
  • Retrospective Studies