The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

Satrialdi; Reina Munechika; Vasudevanpillai Biju; Yuta Takano; Hideyoshi Harashima; Yuma Yamada

doi:10.1039/c9cc08563g

The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

Chem Commun (Camb). 2020 Jan 23;56(7):1145-1148. doi: 10.1039/c9cc08563g.

Authors

Satrialdi¹, Reina Munechika², Vasudevanpillai Biju³, Yuta Takano³, Hideyoshi Harashima², Yuma Yamada²

Affiliations

¹ Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. u-ma@pharm.hokudai.ac.jp and School of Pharmacy, Institut Teknologi Bandung, Ganesha 10, Bandung 40132, Indonesia.
² Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. u-ma@pharm.hokudai.ac.jp.
³ Research Institute for Electronic Science, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, Japan. tak@es.hokudai.ac.jp and Graduate School of Environmental Science, Hokkaido University, Kita-10 Nishi-5, Kita-ku, Sapporo 060-0810, Japan.

PMID: 31895356
DOI: 10.1039/c9cc08563g

Abstract

The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy.