Abstract
We prepared novel conjugated polymer based NIR-II nanoparticles, which display extremely high photothermal conversion efficiency (65%). Both in vitro and in vivo investigations revealed that the as-prepared nanoparticles exhibit excellent theranostic properties including an extremely high cancer cell killing ability, admirable tumor elimination efficiency (100%) and a remarkable photoacoustic imaging contrast enhancing ability.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / therapeutic use*
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Hep G2 Cells
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Humans
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Hyperthermia, Induced / methods
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Infrared Rays
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Mice
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Microscopy, Confocal / methods
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Microscopy, Fluorescence / methods
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Nanoparticles / chemistry
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Nanoparticles / radiation effects
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Nanoparticles / therapeutic use*
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Organosilicon Compounds / chemistry
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Organosilicon Compounds / radiation effects
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Organosilicon Compounds / therapeutic use*
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Photoacoustic Techniques / methods
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Polymers / chemistry
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Polymers / radiation effects
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Polymers / therapeutic use*
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Theranostic Nanomedicine / methods
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Thiadiazoles / chemistry
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Thiadiazoles / radiation effects
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Thiadiazoles / therapeutic use*
Substances
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Antineoplastic Agents
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Organosilicon Compounds
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Polymers
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Thiadiazoles