Donor-acceptor conjugated polymer-based nanoparticles for highly effective photoacoustic imaging and photothermal therapy in the NIR-II window

Chem Commun (Camb). 2020 Jan 23;56(7):1093-1096. doi: 10.1039/c9cc07821e.

Abstract

We prepared novel conjugated polymer based NIR-II nanoparticles, which display extremely high photothermal conversion efficiency (65%). Both in vitro and in vivo investigations revealed that the as-prepared nanoparticles exhibit excellent theranostic properties including an extremely high cancer cell killing ability, admirable tumor elimination efficiency (100%) and a remarkable photoacoustic imaging contrast enhancing ability.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / radiation effects
  • Antineoplastic Agents / therapeutic use*
  • Hep G2 Cells
  • Humans
  • Hyperthermia, Induced / methods
  • Infrared Rays
  • Mice
  • Microscopy, Confocal / methods
  • Microscopy, Fluorescence / methods
  • Nanoparticles / chemistry
  • Nanoparticles / radiation effects
  • Nanoparticles / therapeutic use*
  • Organosilicon Compounds / chemistry
  • Organosilicon Compounds / radiation effects
  • Organosilicon Compounds / therapeutic use*
  • Photoacoustic Techniques / methods
  • Polymers / chemistry
  • Polymers / radiation effects
  • Polymers / therapeutic use*
  • Theranostic Nanomedicine / methods
  • Thiadiazoles / chemistry
  • Thiadiazoles / radiation effects
  • Thiadiazoles / therapeutic use*

Substances

  • Antineoplastic Agents
  • Organosilicon Compounds
  • Polymers
  • Thiadiazoles