Poor delimitation from the viable brain, great genetic heterogeneity, lack of tumor vascularisation are factors that preclude intravenous chemotherapy. Interstitial chemotherapy could be a strategy to avoid a blood-brain barrier and to assure a minimal dose concentration of the chemotherapy agent. Doxorubicin might be devoid of neurotoxic effects and still efficient on remaining far-infiltrated tumor cells.
Keywords: doxorubicin; glioblastoma; interstitial chemotherapy; recurrence; stem cell culture.
© 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.