Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans

Anticancer Res. 2020 Jan;40(1):27-34. doi: 10.21873/anticanres.13923.

Abstract

Background/aim: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking.

Materials and methods: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

Results: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer.

Conclusion: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.

Keywords: African-American; Single nucleotide polymorphisms; inflammation; interleukin 10; prostate cancer; smoking.

MeSH terms

  • Aged
  • Alleles
  • Biomarkers
  • Black or African American / genetics*
  • Case-Control Studies
  • Disease Susceptibility
  • Genotype
  • Haplotypes
  • Humans
  • Interleukin-10 / genetics*
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic*
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / pathology
  • Risk Assessment
  • Risk Factors
  • Smoking / adverse effects*

Substances

  • Biomarkers
  • IL10 protein, human
  • Interleukin-10