Exfoliated MXene as a mediator for efficient laser desorption/ionization mass spectrometry analysis of various analytes

Ari Chae; Hongje Jang; Dong-Yeun Koh; Cheol-Min Yang; Young-Kwan Kim

doi:10.1016/j.talanta.2019.120531

Exfoliated MXene as a mediator for efficient laser desorption/ionization mass spectrometry analysis of various analytes

Talanta. 2020 Mar 1:209:120531. doi: 10.1016/j.talanta.2019.120531. Epub 2019 Nov 3.

Authors

Ari Chae¹, Hongje Jang², Dong-Yeun Koh³, Cheol-Min Yang⁴, Young-Kwan Kim⁵

Affiliations

¹ Institute of Advanced Composite Materials, Korea Institute of Science and Technology, 92 Chudong-ro, Bongdong-eup, Wanju-gun, Jeonbuk, 55324, South Korea; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea.
² Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul, 01897, South Korea.
³ Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea.
⁴ Institute of Advanced Composite Materials, Korea Institute of Science and Technology, 92 Chudong-ro, Bongdong-eup, Wanju-gun, Jeonbuk, 55324, South Korea.
⁵ Department of Chemistry, Dongguk University-Seoul, 30 Pildong-ro, Jung-gu, Seoul, 04620, South Korea. Electronic address: kimyk@dongguk.edu.

PMID: 31892054
DOI: 10.1016/j.talanta.2019.120531

Abstract

The exfoliated MXene (e-MXene) is systematically investigated as a mediator for laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis. Whereas un-exfoliated MXene has no activity for LDI-MS analysis, the e-MXene presents a high resolution, salt-tolerance and efficiency for LDI-MS analysis of various small molecules regardless of their polarity, aromaticity and molecular weight owing to its physicochemical properties such as high laser energy absorption, electrical conductivity and photothermal conversion. Based on our findings, it is clearly confirmed that e-MXene is a promising material for the development of an efficient platform for LDI-MS analysis of small molecules.

Keywords: Exfoliation; Laser desorption ionization; MXene; Mass spectrometry; Metabolite.