Current role of non-coding RNAs in the clinical setting

Caterina Vicentini; Francesca Galuppini; Vincenzo Corbo; Matteo Fassan

doi:10.1016/j.ncrna.2019.09.001

Current role of non-coding RNAs in the clinical setting

Noncoding RNA Res. 2019 Sep 17;4(3):82-85. doi: 10.1016/j.ncrna.2019.09.001. eCollection 2019 Sep.

Authors

Caterina Vicentini¹, Francesca Galuppini², Vincenzo Corbo¹, Matteo Fassan²

Affiliations

¹ ARC-NET Research Centre, University of Verona, Verona, Italy.
² Department of Medicine (DIMED), University of Padua, Padua, PD, Italy.

Abstract

Non-coding RNAs (ncRNAs) have long been considered as "junk" material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response.

Keywords: Drug resistance; Non-coding RNAs; miRNA-based therapy; miRNAs.

Publication types

Review