α-Gluco-oligosaccharide in the research and development of a polymeric material for modified drug delivery

Frederico Minardi de Oliveira; Élcio José Bunhak; Leandro Freire Dos Santos; Priscila Debastiani Barros; Osvaldo Albuquerque Cavalcanti

doi:10.1016/j.heliyon.2019.e03053

α-Gluco-oligosaccharide in the research and development of a polymeric material for modified drug delivery

Heliyon. 2019 Dec 19;5(12):e03053. doi: 10.1016/j.heliyon.2019.e03053. eCollection 2019 Dec.

Authors

Frederico Minardi de Oliveira¹, Élcio José Bunhak¹, Leandro Freire Dos Santos², Priscila Debastiani Barros¹, Osvaldo Albuquerque Cavalcanti^{1

3}

Affiliations

¹ Universidade Estadual do Oeste do Paraná, Laboratório de Tecnologia Farmacêutica, Cascavel, Paraná, Brazil.
² Universidade Estadual do Centro-Oeste, Departamento de Farmácia, Guarapuava, Paraná, Brazil.
³ Universidade Estadual de Maringá, Departamento de Farmacologia e Terapêutica, Paraná, Brazil.

Abstract

This research aimed to analyse the influence of the incorporation of α-gluco-oligosaccharide (GOS-α) in the formation of isolated films of different combinations of polymethyl by applying physicochemical analyses such as Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG) and scanning electron microscopy (SEM). Polymer films were prepared by evaporation associating Eudragit® RS30D with α-GOS. FTIR results confirmed the incorporation of α-GOS. The intermolecular interaction involving carbonyl and hydroxyl groups of Eudragit® with α-GOS was not detected. By TG and DSC, it was possible to detect that there were no changes in the thermal properties between the proposed combinations and the standard film. Upon SEM analysis, the appearance of pores for the association 90:10 was evidenced. Possibly, these pores act as output ports for the drug. These results sharpen the perspective of applying this material to the coating of pharmaceutical formulations of modified drug delivery.

Keywords: Bioecolians®; Colon; Eudragit®; Materials science; Oligosaccharide; Pharmaceutical science; Polymethylmethacrylate.